ALG2

Across TCGA patient cohorts, ALG2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG2-associated genes across cancer lineages are 14-3-3_beta, Gab2, and ACVRL1. Each is linked with ALG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG2-to-partner and partner-to-ALG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ALG2-low versus ALG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG2→partner) and Y-score (partner→ALG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.123	-2.571	.008	.011	3	1
UCEC	Gab2 →	+0.340	+2.584	.041	.011	3	1
UCEC	ACVRL1 →	-0.167	-3.439	.008	.005	3	1
UCEC	JNK2 →	+0.257	+3.179	.005	.010	3	1
UCEC	MEK1 →	+0.443	+3.321	.009	.010	3	1
UCEC	Annexin-1 →	+0.591	+2.999	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by ALG2 expression — UCEC

Explore this box plot interactively →