ALG2

Across TCGA cell cohorts, ALG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,300 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ALG2-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Establishment of protein localization to endoplasmic reticulum, and Cellular response to topologically incorrect protein. Each is linked with ALG2 in more than 14 cancer types. Because this analysis shows association rather than direction, both ALG2-to-partner and partner-to-ALG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by ALG2-low versus ALG2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG2→partner) and Y-score (partner→ALG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	+0.117	+1.221	<.001	<.001	3	15
BONE	Establishment of protein localization to endoplasmic reticulum →	+0.110	+0.574	<.001	.002	3	14
OESOPHAGUS	Cellular response to topologically incorrect protein →	+0.121	+1.182	<.001	<.001	3	13
BONE	Response to topologically incorrect protein →	+0.093	+0.559	<.001	<.001	3	12
BONE	Protein targeting to ER →	+0.096	+0.625	.001	.001	2	13
BONE	Endoplasmic reticulum organization →	+0.088	+0.635	.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,300 associations by consensus.

Response to endoplasmic reticulum stress by ALG2 expression — BLOOD_Myeloma

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