ALG1L2

Across TCGA cell cohorts, ALG1L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,181 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALG1L2-associated GO terms across cancer lineages are mRNA splice site recognition, Regulation of alternative mRNA splicing, via spliceosome, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with ALG1L2 in more than 8 cancer types. Because this analysis shows association rather than direction, both ALG1L2-to-partner and partner-to-ALG1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by ALG1L2-low versus ALG1L2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1L2→partner) and Y-score (partner→ALG1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	mRNA splice site recognition →	+0.091	+0.093	<.001	<.001	3	9
PANCREAS	Regulation of alternative mRNA splicing, via spliceosome →	+0.088	+0.414	<.001	.005	3	8
BREAST	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.142	+0.219	<.001	.001	3	8
PANCREAS	Negative regulation of transcription initiation by RNA polymerase II →	+0.085	+0.302	.004	.003	3	7
PANCREAS	Regulation of protein localization to nucleus →	+0.070	+0.381	<.001	<.001	3	7
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.106	+0.375	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,181 associations by consensus.

mRNA splice site recognition by ALG1L2 expression — SOFT_TISSUE

Explore this box plot interactively →