Across TCGA pan-cancer cohorts, ALG12 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ALG12 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ALG12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALG12 expression acts as an unfavorable survival marker.

LSCC, UCEC, and HNSC are the cancer types where ALG12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.832	1.000	.008	28	view →
UCEC	OS	Median	III,IV	0.327	1.000	.004	20	view →
HNSC	DFS	Quartile	III,IV	0.752	0.908	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ALG12 tumor-vs-normal RNA expression · all ALG12 data types