Across TCGA patient cohorts, ALG12 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG12-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and ERK2. Each is linked with ALG12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG12-to-partner and partner-to-ALG12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG12→partner) and Y-score (partner→ALG12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.381	+2.179	.012	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+1.054	+3.700	<.001	.001	3	2
UCEC	ERK2 →	+0.204	+2.999	.022	.035	3	1
UCEC	JNK2 →	+0.302	+2.817	.001	.036	3	1
UCEC	MEK1 →	+0.456	+2.459	.007	.019	3	1
UCEC	MSH2 →	-0.380	-2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ALG12 survival (RNA) · tumor vs normal (RNA) · all ALG12 data types