Across TCGA cell cohorts, ALG12 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALG12-associated genes across cancer lineages are ART5, LCE2C, and CYP2A13. Each is linked with ALG12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG12-to-partner and partner-to-ALG12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG12→partner) and Y-score (partner→ALG12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ART5 →	+0.132	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	LCE2C →	+0.056	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	CYP2A13 →	+0.006	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	USP17L4 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-7 →	+0.126	+5.643	<.001	.002	3	1
BLOOD_Leukemia	NUDT10 →	+0.981	+3.754	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

ALG12 survival (RNA) · tumor vs normal (RNA) · all ALG12 data types