ALG11

Across TCGA patient cohorts, ALG11 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG11-associated genes across cancer lineages are eIF4E, Notch1, and FoxM1. Each is linked with ALG11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG11-to-partner and partner-to-ALG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ALG11-low versus ALG11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG11→partner) and Y-score (partner→ALG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+2.820	.045	.035	3	2
UCEC	Notch1 →	+0.194	+2.335	.001	.018	3	2
UCEC	FoxM1 →	+0.236	+2.222	.031	.011	3	1
UCEC	Ku80 →	+0.231	+2.235	.021	.006	3	1
UCEC	p62 Lck ligand →	+0.387	+2.222	.005	.011	3	1
UCEC	PCNA →	+0.224	+3.321	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by ALG11 expression — UCEC

Explore this box plot interactively →