ALG11

Across TCGA cell cohorts, ALG11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,546 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALG11-associated GO terms across cancer lineages are RNA destabilization, Copper ion export, and mRNA destabilization. Each is linked with ALG11 in more than 12 cancer types. Because this analysis shows association rather than direction, both ALG11-to-partner and partner-to-ALG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA destabilization grouped by ALG11-low versus ALG11-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG11→partner) and Y-score (partner→ALG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RNA destabilization →	+0.068	+0.835	.002	.004	3	13
SOFT_TISSUE	Copper ion export →	-0.157	-0.748	<.001	<.001	3	13
STOMACH	mRNA destabilization →	+0.060	+0.795	.007	.006	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.180	+1.227	<.001	<.001	3	13
STOMACH	Retrograde transport, vesicle recycling within Golgi →	+0.139	+0.920	<.001	<.001	3	13
BREAST	Retrograde transport, endosome to Golgi →	+0.067	+0.818	.001	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,546 associations by consensus.

RNA destabilization by ALG11 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →