ALG1

Across TCGA pan-cancer cohorts, ALG1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALG1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ALG1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALG1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where ALG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.817	0.606	.020	14	view →
PDAC	DFS	Tertile	III,IV	0.583	0.181	.011	9	view →
CCRCC	DFS	Tertile	III,IV	0.509	0.836	.011	9	view →
LUAD	OS	Tertile	III,IV	0.743	0.233	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALG1–HNSC (OS)

Open the HNSC breakdown →