ALG1

Across TCGA patient cohorts, ALG1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,884 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ALG1-associated genes across cancer lineages are ZNF221, NUP85, and ANAPC11. Each is linked with ALG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ALG1-to-partner and partner-to-ALG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALG1 versus ZNF221 in HNSC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1→partner) and Y-score (partner→ALG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF221 →	-0.817	-0.279	<.001	.001	3	5
LSCC	NUP85 →	-0.453	-0.230	<.001	<.001	3	4
OV	ANAPC11 →	-0.626	-0.293	.004	.001	3	4
HNSC	PRPSAP1 →	-0.702	-0.251	<.001	.003	3	4
CCRCC	IL17RD →	-1.306	-0.359	<.001	<.001	3	4
BRCA	MTPAP →	-0.431	-0.342	.002	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,884 associations by consensus.

ALG1 vs ZNF221 — HNSC

Explore this scatter interactively →