ALG1

Across TCGA patient cohorts, ALG1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG1-associated genes across cancer lineages are Ku80, MEK1, and PRDX1. Each is linked with ALG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG1-to-partner and partner-to-ALG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ALG1-low versus ALG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1→partner) and Y-score (partner→ALG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.277	+2.335	.019	.020	3	1
UCEC	MEK1 →	+0.442	+3.321	.016	.010	3	1
UCEC	PRDX1 →	+0.233	+3.000	.024	.036	3	1
UCEC	Rictor_pT1135 →	-0.159	-3.459	.002	.005	3	1
UCEC	YAP →	+0.153	+3.009	.042	.019	3	1
UCEC	Bad_pS112 →	-0.197	-3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by ALG1 expression — UCEC

Explore this box plot interactively →