ALG1

Across TCGA cell cohorts, ALG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,903 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ALG1-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Multi-pass transmembrane protein insertion into ER membrane. Each is linked with ALG1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ALG1-to-partner and partner-to-ALG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by ALG1-low versus ALG1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1→partner) and Y-score (partner→ALG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	rRNA 5'-end processing →	+0.137	+1.333	.007	<.001	3	13
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.137	+1.333	.007	<.001	3	13
LUNG_SCLC	Multi-pass transmembrane protein insertion into ER membrane →	+0.148	+0.611	<.001	.004	3	13
LARGE_INTESTINE	rRNA pseudouridine synthesis →	+0.100	+0.778	<.001	<.001	3	10
SOFT_TISSUE	Calcium-independent cell-matrix adhesion →	+0.140	+0.567	<.001	.003	3	10
PANCREAS	Enzyme-directed rRNA pseudouridine synthesis →	+0.095	+0.746	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,903 associations by consensus.

rRNA 5'-end processing by ALG1 expression — BLOOD_Myeloma

Explore this box plot interactively →