ALDOC

Across TCGA pan-cancer cohorts, ALDOC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALDOC data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ALDOC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALDOC expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

PDAC, COAD, and LUAD are the cancer types where ALDOC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.711	0.878	.010	15	view →
COAD	DFS	Median	II,III,IV	1.000	0.912	.014	12	view →
LUAD	DFS	Median	All	0.523	0.749	.019	4	view →
CCRCC	DFS	Median	II,III,IV	0.191	0.820	.039	4	view →
GBM	DFS	Quartile	All	0.259	0.523	.042	4	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALDOC–PDAC (DFS)

Open the PDAC breakdown →