ALDOB

Across TCGA cell cohorts, ALDOB mutation is significantly associated with the mutation status of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALDOB-associated genes across cancer lineages are PPL, UTP20, and UPF1. Each is linked with ALDOB in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDOB-to-partner and partner-to-ALDOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPL grouped by ALDOB-low versus ALDOB-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDOB→partner) and Y-score (partner→ALDOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPL →	+2.830	+3.548	.009	.009	1	3
SKIN	UTP20 →	+2.830	+3.548	.009	.009	1	3
LUNG_SCLC	UPF1 →	+4.502	+5.066	.007	.007	1	3
SKIN	MAPK8IP3 →	+3.638	+4.117	.002	.002	1	2
SKIN	GREB1L →	+4.468	+5.532	<.001	<.001	1	2
SKIN	PNMT →	+5.053	+4.239	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

PPL by ALDOB expression — SKIN

Explore this box plot interactively →