ALDOA

Across TCGA cell cohorts, ALDOA mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALDOA-associated genes across cancer lineages are ATP6V1G3, USP17L3, and DYTN. Each is linked with ALDOA in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDOA-to-partner and partner-to-ALDOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1G3 grouped by ALDOA-low versus ALDOA-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDOA→partner) and Y-score (partner→ALDOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ATP6V1G3 →	+0.260	+4.108	.001	.005	3	1
LUNG_NSCLC_LUSC	USP17L3 →	+0.024	+4.584	.001	.001	3	1
LUNG_NSCLC_LUSC	DYTN →	+0.007	+4.108	<.001	.005	3	1
BLOOD_Leukemia	OR10T2 →	+0.558	+4.276	.007	.007	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.061	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ATP6V1G3 by ALDOA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →