ALDH9A1

Across TCGA pan-cancer cohorts, ALDH9A1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ALDH9A1 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ALDH9A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALDH9A1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

MESO, SKCM, and UCEC are the cancer types where ALDH9A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.069	0.580	<.001	36	view →
SKCM	DFS	Median	All	1.000	0.599	.012	16	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ALDH9A1–MESO (OS)

Open the MESO breakdown →