ALDH9A1

Across TCGA patient cohorts, ALDH9A1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH9A1-associated genes across cancer lineages are EGFR_pY1068, FASN, and p70-S6K. Each is linked with ALDH9A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH9A1-to-partner and partner-to-ALDH9A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ALDH9A1-low versus ALDH9A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH9A1→partner) and Y-score (partner→ALDH9A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.315	-2.700	.001	.006	3	2
UCEC	FASN →	+0.307	+1.584	.047	.036	3	2
UCEC	p70-S6K →	+0.175	+1.611	.020	.022	3	2
UCEC	PCNA →	+0.203	+3.169	.017	.018	3	2
UCEC	ATM →	-0.571	-2.584	.001	.010	3	2
COAD	Caspase-7-cleavedD198 →	+1.403	+2.815	.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EGFR_pY1068 by ALDH9A1 expression — UCEC

Explore this box plot interactively →