ALDH9A1

Across TCGA cell cohorts, ALDH9A1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALDH9A1-associated genes across cancer lineages are IZUMO2, TBC1D3H, and ASPN. Each is linked with ALDH9A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH9A1-to-partner and partner-to-ALDH9A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO2 grouped by ALDH9A1-low versus ALDH9A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH9A1→partner) and Y-score (partner→ALDH9A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IZUMO2 →	+0.202	+4.544	.002	.003	3	1
LUNG_NSCLC_LUAD	TBC1D3H →	+1.399	+4.371	<.001	.005	3	1
LARGE_INTESTINE	ASPN →	+0.037	+3.841	.001	<.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.012	+3.474	.008	.003	3	1
LARGE_INTESTINE	RPF1 →	+0.612	+3.087	.009	.006	3	1
LARGE_INTESTINE	GTF2B →	+0.417	+3.215	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IZUMO2 by ALDH9A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →