ALDH7A1

Across TCGA patient cohorts, ALDH7A1 mutation is significantly associated with the RNA expression of many other genes, with 489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH7A1-associated genes across cancer lineages are RPL23AP82, SNORD126, and RN7SL479P. Each is linked with ALDH7A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH7A1-to-partner and partner-to-ALDH7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by ALDH7A1-low versus ALDH7A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH7A1→partner) and Y-score (partner→ALDH7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.412	+3.467	.004	.002	3	2
UCEC	SNORD126 →	+0.414	+2.418	<.001	.005	3	2
UCEC	RN7SL479P →	+0.083	+3.226	.005	.005	3	2
UCEC	MIR6781 →	+0.587	+2.236	<.001	.003	3	2
SKCM	RNU4-14P →	+0.310	+2.728	.003	.006	3	2
HNSC	MIR449B →	+0.323	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

RPL23AP82 by ALDH7A1 expression — UCEC

Explore this box plot interactively →