ALDH7A1

Across TCGA patient cohorts, ALDH7A1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH7A1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and GAPDH. Each is linked with ALDH7A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH7A1-to-partner and partner-to-ALDH7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ALDH7A1-low versus ALDH7A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH7A1→partner) and Y-score (partner→ALDH7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.257	-2.459	.034	.020	3	1
UCEC	ERK2 →	+0.234	+3.169	.011	.019	3	1
UCEC	GAPDH →	+0.640	+3.169	.013	.018	3	1
UCEC	p62 Lck ligand →	+0.446	+2.179	.004	.034	3	1
UCEC	ATM →	-0.732	-3.156	<.001	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+0.990	+3.189	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by ALDH7A1 expression — UCEC

Explore this box plot interactively →