ALDH6A1

Across TCGA pan-cancer cohorts, ALDH6A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALDH6A1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ALDH6A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALDH6A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and UCEC are the cancer types where ALDH6A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.888	.003	43	view →
COAD	DFS	Quartile	All	1.000	0.890	.040	12	view →
UCEC	DFS	Median	All	0.935	1.000	.020	10	view →
PDAC	OS	Quartile	II,III,IV	0.919	0.627	.019	6	view →
GBM	DFS	Median	All	0.199	0.423	.006	4	view →
LUAD	OS	Median	II,III,IV	1.000	0.501	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALDH6A1–CCRCC (OS)

Open the CCRCC breakdown →