ALDH6A1

Across TCGA patient cohorts, ALDH6A1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH6A1-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and Notch1. Each is linked with ALDH6A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH6A1-to-partner and partner-to-ALDH6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ALDH6A1-low versus ALDH6A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH6A1→partner) and Y-score (partner→ALDH6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.834	+2.827	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.085	-3.143	.027	.018	3	1
UCEC	Notch1 →	+0.190	+2.087	<.001	.005	3	1
UCEC	p62 Lck ligand →	+0.358	+2.125	.004	.010	3	1
UCEC	Annexin-1 →	+0.764	+3.720	<.001	<.001	3	1
UCEC	BRD4 →	+0.251	+1.595	.014	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by ALDH6A1 expression — UCEC

Explore this box plot interactively →