ALDH6A1

Across TCGA cell cohorts, ALDH6A1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALDH6A1-associated genes across cancer lineages are HSFY1, FTMT, and MAGEB4. Each is linked with ALDH6A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH6A1-to-partner and partner-to-ALDH6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY1 grouped by ALDH6A1-low versus ALDH6A1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH6A1→partner) and Y-score (partner→ALDH6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HSFY1 →	+0.022	+4.981	<.001	.008	3	1
CNS	FTMT →	+0.036	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	CHRNA2 →	+0.056	+2.938	.001	.003	3	1
LARGE_INTESTINE	MS4A3 →	+0.072	+3.584	.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

HSFY1 by ALDH6A1 expression — CNS

Explore this box plot interactively →