ALDH5A1

Across TCGA pan-cancer cohorts, ALDH5A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALDH5A1 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ALDH5A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALDH5A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, GBM, and LUAD are the cancer types where ALDH5A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.952	0.699	.004	16	view →
GBM	DFS	Quartile	All	0.904	0.582	.004	15	view →
LUAD	OS	Median	All	0.929	0.743	.002	11	view →
CCRCC	OS	Quartile	III,IV	1.000	0.723	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALDH5A1–PDAC (OS)

Open the PDAC breakdown →