ALDH5A1

Across TCGA patient cohorts, ALDH5A1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,990 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ALDH5A1-associated genes across cancer lineages are GPLD1, LOX, and TMEM45A. Each is linked with ALDH5A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ALDH5A1-to-partner and partner-to-ALDH5A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALDH5A1 versus GPLD1 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH5A1→partner) and Y-score (partner→ALDH5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GPLD1 →	+1.002	+0.599	<.001	<.001	3	7
GBM	LOX →	-1.273	-0.517	.001	.001	3	7
BRCA	TMEM45A →	-1.122	-0.632	.001	.001	3	7
BRCA	HIF1A →	-0.770	-0.490	<.001	.002	3	6
GBM	CAV1 →	-1.349	-0.510	<.001	<.001	3	6
UCEC	ITGB1 →	-0.676	-0.494	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,990 associations by consensus.

ALDH5A1 vs GPLD1 — HNSC

Explore this scatter interactively →