ALDH5A1

Across TCGA patient cohorts, ALDH5A1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH5A1-associated genes across cancer lineages are p70-S6K_pT389, ATM, and JNK2. Each is linked with ALDH5A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH5A1-to-partner and partner-to-ALDH5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by ALDH5A1-low versus ALDH5A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH5A1→partner) and Y-score (partner→ALDH5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.197	-2.459	.004	.018	3	2
UCEC	ATM →	-0.329	-2.000	.048	.030	3	2
UCEC	JNK2 →	+0.177	+1.847	.015	.008	3	1
UCEC	MEK1 →	+0.469	+2.736	<.001	<.001	3	1
UCEC	MSH2 →	-0.237	-1.781	.005	.024	3	1
UCEC	p62 Lck ligand →	+0.378	+2.807	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p70-S6K_pT389 by ALDH5A1 expression — UCEC

Explore this box plot interactively →