ALDH3B2

Across TCGA cell cohorts, ALDH3B2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALDH3B2-associated genes across cancer lineages are ZNRF4, PRAMEF1, and TCF21. Each is linked with ALDH3B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH3B2-to-partner and partner-to-ALDH3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by ALDH3B2-low versus ALDH3B2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH3B2→partner) and Y-score (partner→ALDH3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNRF4 →	+0.015	+4.887	<.001	.009	3	1
BLOOD_Leukemia	PRAMEF1 →	+0.010	+4.984	<.001	.002	3	1
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.165	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR10V1 →	+0.028	+4.984	<.001	.002	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ZNRF4 by ALDH3B2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →