ALDH3A2

Across TCGA cell cohorts, ALDH3A2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALDH3A2-associated genes across cancer lineages are TBC1D21, TAFA1, and SPRR2F. Each is linked with ALDH3A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH3A2-to-partner and partner-to-ALDH3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by ALDH3A2-low versus ALDH3A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH3A2→partner) and Y-score (partner→ALDH3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	SPRR2F →	+0.434	+3.029	.003	.006	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
LARGE_INTESTINE	PTX4 →	+0.091	+3.520	.005	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TBC1D21 by ALDH3A2 expression — LARGE_INTESTINE

Explore this box plot interactively →