ALDH3A1

Across TCGA pan-cancer cohorts, ALDH3A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALDH3A1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ALDH3A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ALDH3A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where ALDH3A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.795	1.000	.005	27	view →
PDAC	DFS	Quartile	II,III,IV	0.489	0.265	.015	10	view →
GBM	OS	Median	All	0.239	0.531	.013	9	view →
UCEC	OS	Quartile	All	0.888	1.000	.041	6	view →
HNSC	OS	Median	II,III,IV	0.935	0.991	.024	3	view →
CCRCC	OS	Quartile	All	0.779	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALDH3A1–LUAD (OS)

Open the LUAD breakdown →