ALDH3A1

Across TCGA patient cohorts, ALDH3A1 mutation is significantly associated with the RNA expression of many other genes, with 1,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH3A1-associated genes across cancer lineages are PRSS53, FAM177A1, and PAXIP1. Each is linked with ALDH3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH3A1-to-partner and partner-to-ALDH3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS53 grouped by ALDH3A1-low versus ALDH3A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH3A1→partner) and Y-score (partner→ALDH3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRSS53 →	+0.290	+2.892	<.001	.001	3	2
SKCM	FAM177A1 →	+0.393	+2.700	.005	.006	3	2
UCEC	PAXIP1 →	+0.368	+2.831	.006	.001	3	2
UCEC	SLC30A2 →	-0.875	-1.989	.005	.003	3	2
UCEC	TMUB1 →	+0.410	+3.828	.001	<.001	3	2
UCEC	STOML2 →	+0.388	+2.628	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,512 associations by consensus.

PRSS53 by ALDH3A1 expression — UCEC

Explore this box plot interactively →