ALDH2

Across TCGA pan-cancer cohorts, ALDH2 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated ALDH2 data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ALDH2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALDH2 expression acts as an unfavorable survival marker.

HNSC are the cancer types where ALDH2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.161	0.710	.007	42	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

ALDH2–HNSC (DFS)

Open the HNSC breakdown →