ALDH2

Across TCGA pan-cancer cohorts, ALDH2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ALDH2 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ALDH2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ALDH2 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where ALDH2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.919	.013	60	view →
PDAC	OS	Quartile	All	0.670	0.440	.009	21	view →
HNSC	OS	Median	All	1.000	0.449	.023	12	view →
CCRCC	OS	Median	All	0.960	0.826	.027	8	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.203	.032	7	view →
UCEC	DFS	Median	All	0.963	0.844	.021	6	view →
LSCC	DFS	Median	All	0.621	0.783	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ALDH2–COAD (DFS)

Open the COAD breakdown →