ALDH2

Across TCGA cell cohorts, ALDH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,641 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ALDH2-associated GO terms across cancer lineages are Primary alcohol catabolic process, Catechol-containing compound catabolic process, and Dopamine catabolic process. Each is linked with ALDH2 in more than 12 cancer types. Because this analysis shows association rather than direction, both ALDH2-to-partner and partner-to-ALDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Primary alcohol catabolic process grouped by ALDH2-low versus ALDH2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH2→partner) and Y-score (partner→ALDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Primary alcohol catabolic process →	+0.212	+2.442	<.001	<.001	3	13
OVARY	Catechol-containing compound catabolic process →	+0.234	+2.017	<.001	<.001	3	11
OVARY	Dopamine catabolic process →	+0.234	+2.017	<.001	<.001	3	11
OVARY	Catecholamine catabolic process →	+0.234	+2.017	<.001	<.001	3	11
LARGE_INTESTINE	Isocitrate metabolic process →	+0.118	+1.688	<.001	<.001	3	10
PANCREAS	Cellular response to aldehyde →	+0.137	+1.943	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,641 associations by consensus.

Primary alcohol catabolic process by ALDH2 expression — LUNG_NSCLC_LUAD

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