ALDH1L2

Across TCGA patient cohorts, ALDH1L2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1L2-associated genes across cancer lineages are p62 Lck ligand, p70-S6K, and PCNA. Each is linked with ALDH1L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH1L2-to-partner and partner-to-ALDH1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ALDH1L2-low versus ALDH1L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1L2→partner) and Y-score (partner→ALDH1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.251	+2.594	.039	.006	3	3
UCEC	p70-S6K →	+0.150	+3.479	.037	.002	3	3
UCEC	PCNA →	+0.186	+2.115	.021	.017	3	3
UCEC	4E-BP1 →	+0.230	+1.904	.023	.029	3	3
UCEC	PI3K-p110-a →	-0.142	-1.765	.031	.014	3	2
UCEC	Shc_pY317 →	-0.226	-3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p62 Lck ligand by ALDH1L2 expression — UCEC

Explore this box plot interactively →