ALDH1L2

Across TCGA cell cohorts, ALDH1L2 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALDH1L2-associated genes across cancer lineages are TBL1Y, ZSCAN1, and FOXR2. Each is linked with ALDH1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH1L2-to-partner and partner-to-ALDH1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by ALDH1L2-low versus ALDH1L2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1L2→partner) and Y-score (partner→ALDH1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	2
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	FOXR2 →	+0.006	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUSC	PRAMEF1 →	+0.062	+3.137	<.001	.003	3	1
LUNG_NSCLC_LUSC	FCRL2 →	+0.064	+3.321	.003	.007	3	1
LUNG_NSCLC_LUSC	PPEF2 →	+0.072	+3.736	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

TBL1Y by ALDH1L2 expression — PANCREAS

Explore this box plot interactively →