ALDH1L1

Across TCGA pan-cancer cohorts, ALDH1L1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALDH1L1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ALDH1L1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALDH1L1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where ALDH1L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.936	0.745	.008	20	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	OS	Median	II,III,IV	0.858	0.998	.035	3	view →
PDAC	OS	Median	All	0.889	0.760	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALDH1L1–CCRCC (OS)

Open the CCRCC breakdown →