ALDH1L1

Across TCGA patient cohorts, ALDH1L1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1L1-associated genes across cancer lineages are PDCD4, TFRC, and eIF4E. Each is linked with ALDH1L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ALDH1L1-to-partner and partner-to-ALDH1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ALDH1L1-low versus ALDH1L1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1L1→partner) and Y-score (partner→ALDH1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.454	-3.459	.011	.005	3	5
COAD	TFRC →	+0.624	+2.025	.003	.017	3	4
COAD	eIF4E →	+0.213	+3.169	.003	.017	3	3
UCEC	mTOR_pS2448 →	-0.087	-1.649	.028	.009	3	3
UCEC	Annexin_VII →	-0.080	-0.906	.030	.041	3	3
UCEC	ASNS →	+0.266	+1.201	.005	.025	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

PDCD4 by ALDH1L1 expression — SKCM

Explore this box plot interactively →