Across TCGA pan-cancer cohorts, ALDH1A3 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ALDH1A3 data layer compared with 29 for mass-spec protein and 4 for mass-spec protein.
The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ALDH1A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALDH1A3 expression acts as an unfavorable survival marker.
BRCA, KICH, and LAML are the cancer types where ALDH1A3 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.