Across TCGA pan-cancer cohorts, ALDH1A3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALDH1A3 data layer compared with 29 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALDH1A3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALDH1A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, CCRCC, and GBM are the cancer types where ALDH1A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.901	.006	26	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	9	view →
GBM	DFS	Median	All	0.475	0.260	.019	2	view →
LSCC	DFS	Quartile	All	1.000	0.830	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ALDH1A3 tumor-vs-normal RNA expression · all ALDH1A3 data types