ALDH1A2

Across TCGA pan-cancer cohorts, ALDH1A2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALDH1A2 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALDH1A2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ALDH1A2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where ALDH1A2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	32	view →
PDAC	DFS	Median	All	0.480	0.277	.011	6	view →
HNSC	DFS	Quartile	II,III,IV	0.860	0.988	.022	4	view →
LSCC	DFS	Median	All	0.929	0.615	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALDH1A2–UCEC (OS)

Open the UCEC breakdown →