ALDH1A2

Across TCGA patient cohorts, ALDH1A2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1A2-associated genes across cancer lineages are PCNA, 14-3-3_beta, and eIF4E. Each is linked with ALDH1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH1A2-to-partner and partner-to-ALDH1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ALDH1A2-low versus ALDH1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A2→partner) and Y-score (partner→ALDH1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.177	+3.169	.046	.018	3	2
UCEC	14-3-3_beta →	-0.120	-2.432	.003	.018	3	1
UCEC	eIF4E →	+0.245	+3.000	.004	.001	3	1
UCEC	Gab2 →	+0.391	+2.459	.007	.019	3	1
UCEC	ACVRL1 →	-0.133	-2.439	.018	.019	3	1
UCEC	MEK1 →	+0.449	+3.000	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PCNA by ALDH1A2 expression — UCEC

Explore this box plot interactively →