ALDH1A2

Across TCGA cell cohorts, ALDH1A2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ALDH1A2-associated genes across cancer lineages are OR56A1, TNP1, and RLN3. Each is linked with ALDH1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH1A2-to-partner and partner-to-ALDH1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A1 grouped by ALDH1A2-low versus ALDH1A2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A2→partner) and Y-score (partner→ALDH1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR56A1 →	+0.315	+4.189	<.001	.002	3	2
SOFT_TISSUE	TNP1 →	+1.481	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.041	+5.369	<.001	.004	3	1
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR56A4 →	+0.174	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	DEFB108B →	+0.131	+4.786	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR56A1 by ALDH1A2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →