ALDH18A1

Across TCGA pan-cancer cohorts, ALDH18A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALDH18A1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ALDH18A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALDH18A1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where ALDH18A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.337	0.738	<.001	63	view →
PDAC	DFS	Quartile	III,IV	0.443	0.984	.002	19	view →
GBM	OS	Median	All	0.383	0.685	<.001	14	view →
LUAD	OS	Quartile	All	0.699	0.937	.017	5	view →
HNSC	OS	Tertile	All	0.751	0.913	.029	2	view →
LSCC	OS	Tertile	II,III,IV	0.945	0.683	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALDH18A1–CCRCC (DFS)

Open the CCRCC breakdown →