ALDH18A1

Across TCGA patient cohorts, ALDH18A1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,745 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ALDH18A1-associated genes across cancer lineages are LRRK2, CTSG, and FLI1. Each is linked with ALDH18A1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ALDH18A1-to-partner and partner-to-ALDH18A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALDH18A1 versus LRRK2 in LSCC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH18A1→partner) and Y-score (partner→ALDH18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRRK2 →	-1.164	-0.277	<.001	<.001	3	8
HNSC	CTSG →	-0.970	-0.207	.002	.004	3	7
COAD	FLI1 →	-0.648	-0.448	<.001	<.001	3	7
COAD	LGALS2 →	-1.149	-0.425	<.001	<.001	3	6
LUAD	CEACAM4 →	-0.896	-0.501	<.001	<.001	3	6
UCEC	PYCR1 →	+1.279	+0.545	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,745 associations by consensus.

ALDH18A1 vs LRRK2 — LSCC

Explore this scatter interactively →