ALDH18A1

Across TCGA patient cohorts, ALDH18A1 mutation is significantly associated with the RNA expression of many other genes, with 3,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH18A1-associated genes across cancer lineages are RNU6-800P, RNU7-176P, and ATP5MGP5. Each is linked with ALDH18A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH18A1-to-partner and partner-to-ALDH18A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-800P grouped by ALDH18A1-low versus ALDH18A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH18A1→partner) and Y-score (partner→ALDH18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-800P →	+0.122	+3.069	.007	.009	3	3
HNSC	RNU7-176P →	+0.499	+5.015	.007	.009	3	2
HNSC	ATP5MGP5 →	+0.181	+5.069	<.001	.008	3	2
HNSC	CCDC34P1 →	+0.116	+5.182	<.001	.007	3	2
UCEC	ESS2 →	+0.291	+2.470	.001	<.001	3	2
UCEC	ASCC2 →	+0.272	+3.786	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,059 associations by consensus.

RNU6-800P by ALDH18A1 expression — SKCM

Explore this box plot interactively →