ALDH18A1

Across TCGA cell cohorts, ALDH18A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,989 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ALDH18A1-associated GO terms across cancer lineages are Ornithine metabolic process, L-proline biosynthetic process, and Citrulline biosynthetic process. Each is linked with ALDH18A1 in more than 18 cancer types. Because this analysis shows association rather than direction, both ALDH18A1-to-partner and partner-to-ALDH18A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ornithine metabolic process grouped by ALDH18A1-low versus ALDH18A1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH18A1→partner) and Y-score (partner→ALDH18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Ornithine metabolic process →	+0.180	+0.881	<.001	<.001	3	19
URINARY_TRACT	L-proline biosynthetic process →	+0.169	+0.855	.002	<.001	2	14
UPPER_AERODIGESTIVE_TRACT	Citrulline biosynthetic process →	+0.202	+1.067	.005	<.001	3	11
SKIN	L-proline metabolic process →	+0.132	+0.837	<.001	<.001	3	11
URINARY_TRACT	IMP biosynthetic process →	+0.238	+0.975	<.001	<.001	3	10
URINARY_TRACT	GMP biosynthetic process →	+0.213	+0.845	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,989 associations by consensus.

Ornithine metabolic process by ALDH18A1 expression — LUNG_SCLC

Explore this box plot interactively →