ALDH16A1

Across TCGA pan-cancer cohorts, ALDH16A1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ALDH16A1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ALDH16A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALDH16A1 expression acts as an unfavorable survival marker.

THYM, KIRC, and LAML are the cancer types where ALDH16A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.967	<.001	39	view →
KIRC	DFS	Median	All	0.180	0.796	.001	18	view →
LAML	DFS	Median	All	0.140	0.582	.020	12	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
CESC	OS	Median	All	0.121	0.588	.035	6	view →
LIHC	OS	Median	All	0.442	0.786	.016	6	view →
BLCA	OS	Median	III,IV	0.427	0.689	.048	3	view →
SKCM	OS	Median	III,IV	0.569	0.845	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ALDH16A1–THYM (OS)

Open the THYM breakdown →