ALDH16A1

Across TCGA pan-cancer cohorts, ALDH16A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ALDH16A1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ALDH16A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALDH16A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where ALDH16A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.774	0.371	.008	14	view →
PDAC	DFS	Tertile	All	0.546	0.235	.004	14	view →
UCEC	DFS	Median	III,IV	0.386	1.000	.002	14	view →
HNSC	DFS	Median	IV	0.562	0.810	.010	11	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.353	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ALDH16A1–CCRCC (OS)

Open the CCRCC breakdown →