ALDH16A1

Across TCGA patient cohorts, ALDH16A1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH16A1-associated genes across cancer lineages are PKC-delta_pS664, EGFR_pY1068, and eIF4E. Each is linked with ALDH16A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH16A1-to-partner and partner-to-ALDH16A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by ALDH16A1-low versus ALDH16A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH16A1→partner) and Y-score (partner→ALDH16A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.115	-1.874	.020	.049	3	3
UCEC	EGFR_pY1068 →	-0.220	-2.999	.034	.035	3	2
UCEC	eIF4E →	+0.185	+3.459	.033	.005	3	2
UCEC	ERK2 →	+0.228	+3.169	.004	.018	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.592	+2.321	.004	.006	3	2
UCEC	Rictor_pT1135 →	-0.126	-3.459	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PKC-delta_pS664 by ALDH16A1 expression — UCEC

Explore this box plot interactively →