ALDH16A1

Across TCGA cell cohorts, ALDH16A1 mutation is significantly associated with the mutation status of many other genes, with 3,621 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALDH16A1-associated genes across cancer lineages are CACNA1H, PEX6, and ZBED4. Each is linked with ALDH16A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ALDH16A1-to-partner and partner-to-ALDH16A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1H grouped by ALDH16A1-low versus ALDH16A1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH16A1→partner) and Y-score (partner→ALDH16A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CACNA1H →	+2.637	+3.378	.004	.004	1	5
BLOOD_Leukemia	PEX6 →	+3.135	+3.963	<.001	<.001	1	5
BLOOD_Leukemia	ZBED4 →	+3.083	+3.545	<.001	<.001	1	4
LARGE_INTESTINE	SENP5 →	+3.196	+4.793	<.001	<.001	1	4
LARGE_INTESTINE	TDRD1 →	+3.459	+4.954	<.001	<.001	1	4
BLOOD_Leukemia	ZFP64 →	+2.690	+2.762	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,621 associations by consensus.

CACNA1H by ALDH16A1 expression — BREAST

Explore this box plot interactively →